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. 2016 Mar 14;113(13):E1796–E1805. doi: 10.1073/pnas.1520686113

Fig. 1.

Fig. 1.

Mechanism of ACC inhibition by ND-022. (A) Chemical structure of ND-022. (B) Displacement of Soraphen-TAMARA from hACC2 BC, assessed as a reduction in fluorescence intensity as a function of ND-022. Open circles represent background fluorescence in the absence of hACC2 BC. (C) The shift in thermal stability of hACC2 BC in the presence of either Soraphen A or ND-022. The CT domain-binding inhibitor CP-640186, which does not bind to the BC domain of hACC2, did not produce any shift in hACC2 BC thermal stability. (D) Cocrystal structure of ND-022 complexed with hACC2 BC overlaid with the structure of hACC2 BC complexed with Soraphen A.