Table S4.

Mean ECG parameters in dogs administered vehicle or ND-630 at 100 mg⋅kg⁻¹⋅d⁻¹

Parameter	Male		Female
	Vehicle	ND-630, 100 mg⋅kg−1⋅d−1	Vehicle	ND-630, 100 mg⋅kg−1⋅d−1
Heart rate, bpm
Pretreatment	90	96	105	110
Day 1	75	89	82	100
Day 26	90	88	97	108
PR interval, msec
Pretreatment	86	88	88	85
Day 1	83	84	88	83
Day 26	85	86	89	86
QT interval, msec
Pretreatment	206	198	186	192
Day 1	209	203	196	196
Day 26	202	203	194	200
QTc interval, msec
Pretreatment	232	230	216	230
Day 1	226	229	215	230
Day 26	230	229	224	238

Data are the mean ECG parameters determined for four dogs per sex per group, measured before treatment, after 1 d of treatment, and after 26 d of treatment. bpm, beats per minute.