Fig. 4.
Crystal structures of the L-742,001 inhibitor in complex with the RdRp endonuclease domain from the pandemic H1N1 2009 influenza virus (construct PANΔLoop). (A) Wild-type endonuclease. (B) F105S. (C) E119D. In each figure, the protein secondary structure is shown as a cartoon in gray/blue, amino acids are shown in stick representation with green carbons, L-742,001 is shown in stick with pink carbons, water molecules are shown as red spheres, and metal ions are shown as teal spheres. Hydrogen bonds and metal coordination are displayed by dashed lines. D, E, and F show the 2Fo-Fc electron densities for L-742,001 in A, B, and C, respectively, contoured at 1 σ.