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Regulation of calcium selective ion channels by redox. The oxidizing agent H2O2 or NO directly activates calcium selective channels. In contrast, DTT or extracellular reduced Trx can increase ion current through TRPC5 homotetrameric and TRPC5/TRPC1 heterotetrameric channels. DTT, dithiothreitol; NO, nitric oxide; TRPC, transient-receptor potential cation. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
