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. 2016 Apr 6;3:16023. doi: 10.1038/mtm.2016.23

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Schematic of mechanism proposal for CALAA-01. (a) Nanoparticles are assembled from a linear cyclodextrin-containing polymer (CDP), an adamantane-PEG conjugate (AD-PEG), a targeting component (transferrin, Tf) and the therapeutic gene (siRNA). (b) Nanoparticles are infused into patients. (c) The circulation of nanoparticles and their escape into tumors. (d) Receptor-mediated endocytosis. (e) Interactions between targeted nanoparticles and receptors on the surface of the cancer cell.²⁹ (Copyright 2009 American Chemical Society).