Skip to main content
. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: J Immunol. 2016 Mar 4;196(8):3354–3363. doi: 10.4049/jimmunol.1502687

Figure 5. A single host is able to accommodate responses from multiple minigene constructs.

Figure 5

C57BL/6 mice were co-immunised with Ad-I8V and Ad-D8V or given a single immunisation (individual Ad-I8V or Ad-D8V) (all at 1×108 iu/mouse). (A) Tetramer-specific responses in blood for D8V and I8V in mice immunised intravenously with relevant constructs (B) Responses in blood following co-immunisation via the intramuscular route. Ad-I8V and Ad-D8V were combined in the same mouse, but administered (at the same time) at separate sites. (n=5/group with results showing the mean ± SEM. All work has been performed twice independently showing the same results.) (C) C57BL/6 mice were co-immunised with Ad-I8V, Ad-D8V and Ad-M45 (all at 1×108 iu/mouse) alongside individually immunised animals. (n=8/group – data pooled from 2 experiments - with results showing the mean ± SEM. Statistical analysis on M45: ***p <0.0005.)