Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Functional crosstalk between CD36 and CD47 signaling. In vascular cells ligation of CD36 by amyloid-β or a peptide derived from the type 1 repeats of TSP1 inhibits uptake of free fatty acids via CD36, which regulates eNOS, and inhibits downstream NO/cGMP signaling. The latter pathway requires CD47, but the mechanism remains unclear. One possibility is the lateral association of CD36 with an integrin that also associates with CD47.
