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Extracellular signaling by CD47. CD47 is released by cells in extracellular vesicles known as exosomes. Exosomes are taken up by endothelial cells and T cells and enable transfer of CD47 and the RNA cargo of exosomes to target cells that can alter gene expression and functional responses in the recipient cells in a CD47-dependent manner (Kaur et al., 2014b).
