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CD47 signaling limits stem cell self-renewal. Withdrawal of serum from differentiated cd47-null cells induces their spontaneous reprogramming to multipotent stem cells that can differentiate along all embryonic lineages. Suppression of CD47 in wild type cells using a CD47 morpholino increases expression of stem cell transcription factors and increased asymmetric cell division, whereas treatment with TSP1 or a CD47-binding peptide derived from TSP1 suppresses the stem cell phenotype.
