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. Author manuscript; available in PMC: 2016 Apr 6.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2015 Feb 24;50(3):212–230. doi: 10.3109/10409238.2015.1014024

Fig. 9.

Fig. 9

CD47 regulation of T cell activation and H2S signaling. T cells are activated by T cell receptor (TCR) signaling in response to recognition of antigens presented in the context of MHC or experimentally using an anti-CD3 antibody. TSP1 signaling through CD47 inhibits TCR signaling via several mechanisms including inhibiting induction of the H2S biosynthetic enzymes cystathionine β–synthase (CBS) and cystathionine γ–lyase (CSE). H2S produced by CBS and CSE increases actin polymerization and reorients the microtubule organizing center (MTOC) to enhance immunological synapse formation with antigen-presenting cells.