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Roles of specific ligands in CD47 signaling functions
| Signal | TSP1 peptides | TSP1 | SIRPα/SIRP-Fc | CD47/CD47-Fc |
|---|---|---|---|---|
| Integrin activation | + | + | − | ? |
| calcium | + | + | ? | ? |
| NO/cGMP | + | + | ? | ? |
| BNIP3 translocation | + | ? | − | ? |
| cAMP | + | + | ? | ? |
| autophagy | + | ? | ? | ? |
| Cell death | + | + | ? | ? |
| VEGFR2 activation | ? | + | ? | ? |
| Cell self-renewal: cMyc, Sox2, Klf4, Oct4 |
+ | + | ? | ? |
| Intercellular adhesion | + | + | + | + |
| Neurite and filopodia formation |
? | ? | + | ? |
| NADPH oxidase | ? | + | ? | ? |
| T cell activation | + | + | + | ? |
