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The BCL6 protein represses transcription from the RUVBL1 promoter (transfection assays). Relative luciferase levels in 293 T cells show that RUVBL1 promoter activity is significantly repressed (6.8-fold, p<0.0001) by the full-length BCL6 protein (mean±SEM=0.146±0.059) as compared with a truncated control that lacks the BCL6 zinc fingers and thus cannot bind DNA. The data were normalized with results for the control set at 1.
