Fig. 5.

Immunohistochemistry of representative randomly chosen human lymphomas stained for BCL6 and RUVBL1. The H&E stain shows effacement of normal tissue architecture by malignant cells. Panel 1: T cell tumor, BCL6 negative, RUVBL1 positive. Panel 2: B cell lymphoma, BCL6 negative area, where RUVBL1 is positive. Panel 3: Same B cell lymphoma as in panel 2, BCL6 positive area, where RUVBL1 staining is negative. Panel 4: Germinal center of human tonsil; BCL6 and RUVBL1 are both expressed within the germinal center, but many more lymphocytes outside the germinal center express RUVBL1 as compared with BCL6. The bars in the lower right photos indicate 20 µm for each image in the corresponding panel.