Table 1. ICD-9-CM Codes for Conditions Associated With High-Risk for Respiratory Syncytial Virus Disease and Weighted Estimates of Overall Infant Hospitalization from KID, 1997–2012.
| High-Risk Conditiona | ICD-9-CM Codes | Total Non-Birth Hospitalizations (N)b | Total Birth Hospitalizations (N)b |
|---|---|---|---|
| Chronic respiratory disease arising in the perinatal period (CLD) | 770.7X | 69185 | 48510 |
| Congenital anomalies of the respiratory system | 748.XX | 65910 | 25297 |
| Cystic fibrosis with pulmonary manifestations† | 277.0X | 5537 | 805 |
| Higher-risk congenital heart disease | 425.4X; 428.0X; 745.0X- 745.4X; 745.6X – 745.8; 746.01–746.5X; 746.7X – 746.85; 746.87; 747.1X; 747.21–747.49 | 214061 | 152262 |
| Lower-risk congenital heart disease | 745.5X; 745.9X; 746.00; 746.6X; 746.86; 746.89–746.9X; 747.0X; 747.20; 747.83 | 127566 | 263086 |
| Neuromuscular disease† | 330.XX; 335.XX; 343.XX; 356.XX; 358.1; 359.0X–359.23; 359.9; 775.2 | 10958 | 1369 |
| Down syndrome without congenital heart disease | 758.0X | 13320 | 12549 |
| HIV† | 079.51, 079.52, 079.53 | 9 | 10 |
| Immunodeficiency† | 279.XX | 10370 | 908 |
| Congenital and metabolic† | 740.XX; 741.XX; 742.XX; 754.2; 756.1X; 756.6; 758.1–758.9; 759.3; 759.7X – 759.9X; 271.0; 272.7; 277.5; 277.81; 277.82; 277.86 | 110566 | 68780 |
CHD, congenital heart disease; CLD, congenital lung disease; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; KID, Kids’ Inpatient Database
a If ICD codes for higher-risk CHD and lower-risk CHD were both associated with a hospitalization, the hospitalization was recorded as higher-risk CHD. Down syndrome without CHD is mutually exclusive of higher-risk CHD and lower-risk CHD. Furthermore, the other high-risk group is mutually exclusive of higher-risk CHD, lower-risk CHD, CLD, Down syndrome without CHD, and congenital airway anomalies; preterm birth could not be examined.
b For the calculation of RSV rates by specific conditions, the numerator of the rate was the number of non-birth hospitalizations with the condition of interest who had RSV and the denominator was the number of birth hospitalizations with the condition of interest.
†Cystic fibrosis with pulmonary manifestations, neuromuscular disease, HIV, immunodeficiency, and congenital and metabolic were combined and analyzed as “Other High-risk Conditions” due to the small size of each population.