Table 1. Baseline demographics and outcome.
| No VAC | VAC✽ | p Value | |
|---|---|---|---|
| n = 266 | n = 37 | ||
| Demographics | |||
| Age, y, mean (SD) | 64.9 (14.3) | 63.4 (15.3) | 0.5524 |
| Female, No. (%) | 84 (31.6) | 12 (32.4) | 1.0000 |
| Body weight, kg, mean (SD) | 57.3 (12.2) | 61.5 (11.0) | 0.0438 |
| BMI, mean (SD) | 21.9 (3.7) | 23.0 (4.1) | 0.1056 |
| Brinkman index, mean (SD) | 447.9 (662.2) | 365.9 (476.8) | 0.4682 |
| APACHE Ⅱ score, mean (SD) | 16.8 (6.2) | 21.8 (11.0) | < 0.0001 |
| Charlson comorbidity index, mean (SD) | 1.7 (2.3) | 1.9 (2.5) | 0.7122 |
| ADL, mean (SD)† | 47.0 (48.1) | 22.4 (40.2) | 0.0034 |
| Respiratory function | |||
| P/F, mean (SD) | 292.0 (129.6) | 217.3 (110.8) | 0.0018 |
| OI, mL/cmH2O, mean (SD) | 2.41 (2.12) | 3.44 (2.36) | 0.0117 |
| Tidal volume, mL, mean (SD) | 8.5 (1.5) | 8.2 (1.3) | 0.2526 |
| Cdyn, mean (SD) | 43.9 (21.0) | 38.6 (12.0) | 0.2221 |
| Outcome | |||
| Duration of MV, d, mean (SD) | 8.6 (22.7) | 20.8 (16.4) | 0.0017 |
| ICU length of stay, d, mean (SD) | 10.0 (18.6) | 25.2 (14.2) | < 0.0001 |
| Hospital length of stay, d, mean (SD) | 36.7 (39.7) | 47.0 (32.5) | 0.1317 |
| Mortality-hospital, No. (%) | 31 (11.7) | 11 (29.7) | 0.0084 |
Data are presented as n (%), except where noted otherwise. SD, standard deviation; MV, mechanical ventilation; APACHE, acute physiology and chronic health evaluation; ADL, activities of daily living; BMI, body Mass Index; ICU, intensive care units; P/F, the ratio of arterial oxygen concentration to the fraction of inspired oxygen; OI, oxygen index; Cdyn, dynamic compliance of respiratory system; VAC, ventilator-associated conditions.
*Includes episodes that meet criteria for infected VAC (iVAC) and/or Possible or Probable Pneumonia: pVAP (both subtypes of VAC: iVAC is VAC with general evidence of infection and pVAP is iVAC with lab evidence of pneumonia).
†Activities of daily living (ADL) were assessed using the Barthel index.