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. 2016 Apr 6;11(4):e0153075. doi: 10.1371/journal.pone.0153075

Fig 6. Effects of GSK-3α-deficient cells on the capability of tumor growth in vivo.

Fig 6

(A) Representative images of xenografts derived from control siRNA or GSK-3α siRNA-treated H1993 cells. After 24 h siRNA transfection (20 nM, each), the cells were inoculated subcutaneously into the right and left side dorsal flanks of female nude mice (xenograft n = 7/group). (B) Tumor volume of xenografts derived from control or GSK-3α-deficient H1993 cells were evaluated at each time point as indicated. Tumor volume was measured with digital calipers and calculated by the formula 0.52 x length x width2. Two-sided t-test. *, P < 0.01. (C) Representative images of xenografts derived from H1993-shScrambled, shGSK3A#2, or shGSK3A#4 cells. The cells were inoculated subcutaneously into dorsal flanks of nude mice (left: shScrambled cells, right: shGSK3A cells) and tumor volume was measured over the indicated time points (shScrambled n = 9, shGSK3A#2 n = 4, and shGSK3A#4 n = 5). Two-sided t-test. *, P < 0.05.