Table 1. Hierarchically arranged lists of pathways differentially targeted by AMP-18 in SCC-61 and HaCaT cells.
SCC-61 and HaCaT cells were treated with AMP-18 for 2 h, total RNA was purified and subjected to RNA microarray analysis. Differentially expressed pathways were identified as stated in the Methods with no AMP-18 treatment as a control.
| SCC-61 cells | HaCaT cells | HaCaT vs. SCC-61 cells |
|---|---|---|
| • Fatty acid biosynthesis | • microRNAs in cardiomyocyte hypertrophy | • Selenium pathway |
| • Validated targets of C-MYC transcriptional repression | • (S)-reticuline biosynthesis II | • Immune response IFNα/β signaling pathway |
| • Physiological and pathological hypertrophy of the heart | ||
| • Fatty acid metabolism | • Glypican 2 network | • Cell adhesion-ECM remodeling |
| • Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | • Glycine cleavage | • Collagen biosynthesis and modifying enzymes |
| • P70S6K signaling | • Pyrimidine ribonucleosides salvage I | • Degradation of extracellular matrix |
| • Mitochondrial LC-Fatty acid beta-oxidation | • Guidance cues and growth cone motility | • Metabolism of O-linked glycosylation of mucins |
| • Platelet homeostasis | • Netrin signaling | • Complement and coagulation cascades |
| • LDL oxidation in atherogenesis | • Basal cell carcinoma | • Interferon signaling |
| • MSP-RON signaling | • Defensins | • Cytoskeleton remodeling neurofilaments |
| • Arf1 Pathway | • Sweet taste signaling | • HIF-1 alpha transcription factor network |
| • Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics | • Antiarrhythmic pathway | • PAK pathway |
| • Acetaminphen Pathway, Pharmacokinetics | • Non-integrin membrane-ECM interactions | |
| • Nitric Oxide Stimulates Guanylate Cyclase | • Dissolution of fibrin clot | |
| • AKT Signaling | • All-trans-retinoic acid mediated apoptosis | |
| • Immune Response-MIF-mediated glucocorticoid regulation | • Formation of fibrin clot (clotting cascade) | |
| • Doxorubicin Pathway, Pharmacokinetics | • Matrix metalloproteinases | |
| • CREB Pathway | • Legionellosis | |
| • Axon Guidance | • Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |
| • pERK Regulated gene expression | • Rheumatoid arthritis | |
| • ERK signaling |