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Mean (±SEM) molar ratios of (M + 5) to (M + 0) for 5-formyltetrahydrofolate (A) and 5-methyltetrahydrofolate (B) after IV injection of 214 nmol [13C5]5-formyltetrahydrofolate in 9 subjects. The change in the molar ratio for both [13C5]5-formyl- and [13C5]5-methyltetrahydrofolate was significant (P < 0.0001; repeated-measures ANOVA). IV, intravenous.
