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. 2016 Jan 4;7(3):2159–2174. doi: 10.18632/oncotarget.6818

Figure 1. KRASmut and LGR5 induce distinct embryonic SC-like and intestinal SC programs.

Figure 1

A. GSEA comparing human stage I colon carcinomas to colon adenomas of selected stem cell signatures from MSigDB C2: chemical and Genetic Perturbations gene sets (Broad Institute). B. Expression of embryonic SC genes in human stage I colon carcinomas relative to colon adenomas. C. and D. GSEA on human stage I colon carcinomas versus adenomas using the embryonic SC-like signature (C), the intestinal SC signature (D) and a modified embryonic SC-like signature that lack proliferation and MYC related genes E. F.-H. GSEA on human stage I colon carcinomas and restricted stage I KRASwt and KRASmut subsets that were stratified to LGR5 status using the intestinal SC signature. I.-J. GSEA on human stage I colon carcinomas stratified to KRAS status using the embryonic SC-like signature (I) and intestinal SC signature (J). ES, enrichment score; NES, normalized enrichment score; FDR, false discovery rate.