Figure 1. Aged mice show reduced cardiac ALDH2 activity and increased protein carbonyls.
A. Representative gel blots depicting relative levels of B. p16, C. p53 and D. ALDH2 protein expression in young and aged hearts. The low panel E.-H. show aged mice with Alda-1(ALDH2 activator) treated, young mice were used as control; E. ALDH2 activity; F. 4-HNE protein adduct; G., H. protein carbonyl formation were assessed by quantificational detection (n = 8 per group. *P < 0.05 vs. young control, #P < 0.05 vs. aged group).
