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. 2015 Oct 20;7(3):2284–2296. doi: 10.18632/oncotarget.6198

Figure 2. EZH2 mutations in hematological malignancies.

Figure 2

EZH2 has several functional domains: the WD-40 binding domain (WDB) that interacts with EED; domain 1 (D1); domain 2 (D2) that interacts with SUZ12; the domains SWI3, ADA2, N-CoR and TFIIIB (SANT) that interact with histones; a cysteine-rich domain (CXC); and the suppressor of variegation 3-9, enhancer of zeste and trithorax (SET) catalytic domain. Several EZH2 mutations have been identified in different hematological malignancies: lymphoma (purple star), myelodysplastic syndromes (MDS) and myeloproliferative syndromes (MPS) (blue stars) and T-cell acute lymphoblastic lymphoma (T-ALL) (orange stars).