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. 2015 Oct 25;7(3):2297–2312. doi: 10.18632/oncotarget.6223

Figure 2. MEF2 proteins may act as oncogenes in several types of carcinoma.

Figure 2

A. Alterations affecting MEF2 genes are present in up to 24% of samples of certain cancer types. Shown are data for cancer types in which MEF2 genes were altered in over 8% of cases. In the shown cancer types, MEF2 amplifications were more common than deletions, consistent with the notion that MEF2 genes may act as oncogenes. B. Some MEF2 genes are more frequently affected than others in certain cancer types. The plot shows how in lung squamous cell carcinoma alterations more commonly affect MEF2A and -D than MEF2B and -C. C. In certain cancer types, some MEF2 genes tend to be affected by different types of alterations than other MEF2 genes. The plot shows how in ovarian serous cystadenocarcinoma the copy number alterations affecting MEF2C are deletions, whereas those affecting other MEF2 genes are amplifications. Data and plots were obtained using cBioportal [131, 132].