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. 2015 Nov 12;7(3):2401–2416. doi: 10.18632/oncotarget.6262

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Copyright: © 2016 Ye et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A., C., E. Patients with DLBCL and MYC/BCL2, BCL6/MYC or BCL2/BCL6 co-expression had significantly poorer overall survival in the DBLCL cohort. B. BCL2 overexpression had a synergetic effect with MYC overexpression and the adverse prognostic impact of MYC depended on BCL2 overexpression. D. BCL6 expression had no synergetic effect with MYC expression. F. BCL6 expression appeared to attenuate the adverse prognostic impact of BCL2 overexpression. G. The poorer overall survival of MYC⁺BCL6⁺ patients was due to the poor survival of MYC⁺BCL2⁺ patients. H. Isolated MYC⁺BCL6⁺ versus MYC⁺BCL2⁺ double-positive DLBCL had significantly better patient survival.