Table 3A. The biological function of differentially expressed genes among all samples.
| Gene | function | % change in BRCA1 silenced vs. controls |
|---|---|---|
| LPHN2 | Latrophilin is a G-protein coupled receptors which may function in cell adhesion and signal transduction [77]. | downregulated by 95% (P=4.69E-09) |
| MMP7 | Matrix metallopeptidase 7 is involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes such as arthritis and metastasis [77]. | upregulated by 493% (P=1.20E-05) |
| HSD17B6 | Hydroxysteroid (17-b) dehydrogenase 6 homolog has both oxidoreductase and epimerase activities and is involved in androgen catabolism [77]. | upregulated by 400% (P=4.59E-05) |
| GPRC5B | G protein-coupled receptor may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade [77]. | upregulated by 789% (P=7.25E-09) |
| DHRS9 | Dehydrogenase/reductase, may play a role in the biosynthesis of retinoic acid [77]. | Downregulated by 73% (P=1.6E-04) |
| CCL20 | Chemokine ligand 20 is a chemotactic factor that attracts lymphocytes and neutrophils. It Inhibits proliferation of myeloid progenitors. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells [77]. | Downregulated by 80% (P=1.99E-05) |
| ABCA12 | ATP-binding cassette, sub-family A is a membrane-associated protein, a member of the superfamily of ATP-binding cassette transporters and is involved in transporting various molecules across extra- and intracellular membranes [77]. | downregulated by 500% (P=9.25E-08) |
| HERC5 | A E3 ubiquitin protein ligase 5 which is upregulated in endothelial cells by a pro-inflammatory cytokine. Functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. It acts as a positive regulator of innate antiviral response in cells induced by interferon [77]. | upregulated by 350% (P=2.02E-06) |
| SLC7A11 | Solute carrier family 7, a member of cysteine and glutamate anionic transport system. The predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Increased expression of this gene has been shown in primary glioma [77]. | downregulated by 68% (P=2.8E-04) |
| GDA | Guanine deaminase is responsible for the hydrolytic deamination of guanine and may play a role in microtubule assembly [77]. | Upregulated by 931% (P=1.50E-08) |
| LRCH2 | A member of the leucine-rich repeat and calponin homology domain-containing protein family which contains multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments, functioning as a cytoskeletal scaffold [77]. | upregulated by 821% (P=1.08E-11) |