Table 3B. The biological function of differentially expressed genes in the BRCA1 silenced cells and in vivo in BRCA carriers [ref 32].

Gene	function	% change between samples
CHI3L1	Chitinase 3-like 1 has a proliferative role in stromal fibroblasts and chemotactic effects on endothelial cells. It is involved in angiogenesis and was found to be upregulated in the sera of patients with glioblastoma [77].	upregulated by 107% (P=8E-03)
MUC21	Mucin 21 was reported to be over-expressed in esophageal squamous epithelia and carcinomas [78].	downregulated by 75% (P=1.69E-06)
KLK1	Kallikrein-related peptidase 10 KLK1, a serine protease which is implicated in carcinogenesis and may potentially serve as a novel cancer and other disease biomarkers [77].	upregulated by 113% (P=4.5E-02)
ANXA8	Annexin A8 may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia [77].	downregulated by 44% (P=1.5E-04)
MUC15	Mucin 15 cell-to-matrix adhesion, is associated with poor prognosis of glioma [79]	downregulated by 82% (P=7.38E-06)
TGFβ	plays an important role in carcinogenesis in general and in breast cancer progression in particular [80]	upregulated by 270% (P=1.65E-06)

Changes are between the clones in which BRCA1 was silenced for either one or six months versus the WT intact cells.