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. 2015 Dec 9;7(3):2660–2671. doi: 10.18632/oncotarget.6545

Figure 5. MiR-497 regulates 5-fluorouracil chemosensitivity by targeting KSR1 in colorectal cancer cells.

Figure 5

A. SW1116 cells stably expressing miR-NC or miR-497 were treated with different concentrations of 5-fluorouracil for 48 h, and analyzed by CCK-8 Assay. B. SW1116 cells stably expressing miR-NC, miR-497, or miR-497 in combination with KSR1 overexpression were treated with 4 μM of 5-fluorouracil for indicated time points. Cell proliferation was analyzed by CCK-8 Assay, and cell apoptosis was analyzed by flow cytometry C. and by caspase-3 assay D. Data represent mean ± SD from three replicates. * indicates significant difference at p < 0.05 compared to miR-NC control; ** indicates significant difference at p < 0.01 compared to miR-NC control. # indicates significant difference at p < 0.05 compared to miR-497 and KSR1 overexpression. 5-FU, 5-fluorouracil.