Table 2. IC50 of Anti-CXCR4 antibodies (1D9, 12G5, and BMS-936564) in leukemia/lymphoma cell lines.
| Cell Lines | CXCR4 (ΔMFI) | IC50 (nM) | ||
|---|---|---|---|---|
| BMS-936564 | 12G5 | 1D9 | ||
| JVM2 | 0.65 | NA | NA | NA |
| MEC1 | 0.8 | NA | NA | NA |
| K562 | 1.2 | NA | NA | NA |
| Granta | 4.88 | 25.39 | 19.3 | 45.96 |
| JeKo-1 | 22.75 | 1.86 | 49.41 | 584.47 |
| EW36 | 27.76 | 0.00348 | 1550 | 990 |
| Daudi | 29.78 | 0.000955 | 9.81 | 874.67 |
| Mino | 56.71 | 628.93 | 2650 | 3010 |
| Jurkat | 71.06 | 15.49 | 626.93 | 270.27 |
| Ramos | 76.43 | 3.01 | 24.91 | 1980 |
| Raji | 82.72 | 8.85 | 245.93 | 32.99 |
| Namalwa | 181.2 | 2.57 | 28.52 | 597 |
NA: IC50 not achievable