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. 2015 Dec 20;7(3):2878–2888. doi: 10.18632/oncotarget.6694

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Copyright: © 2016 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) TLE4 increases the JNK-c-Jun pathway activity and expression of cyclin D1 and P27Kip1 in CRC cells. (B) SW480/TLE4 and HT29/TLE4 cells were treated with JNK inhibitor SP600125 (10 μM) for 24 h. Inhibition of the JNK signaling inhibits the promoting effect of TLE4-overexpression on JNK-c-Jun activity in CRC cells. (C, D, E and F) Inhibition of the JNK signaling blocks the promoting effect of TLE4-overexpression on cell proliferation and invasion of CRC cells as determined by MTT assay (C), colony formation assay (D), soft agar assay (E) and migration assay (F) after treatment with SP600125 (10 μM). Error bars represent mean ± SD from 3 independent experiments; *P < 0.01.