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. 2015 Nov 2;7(3):2910–2920. doi: 10.18632/oncotarget.6272

Figure 2. DCA significantly influences the metabolism and proliferation of glycolytic but not oxidative cancer cells.

Figure 2

A. Mitochondrial oxygen consumption rate, B. glucose consumption, C. intracellular ATP content and D. proliferation of MDA-MB-231 (glycolytic) and SiHa (oxidative) human cancer cells after 48 h dichloroacetate (DCA) 5 mM treatment. E. Proliferation of mitochondria-depleted (ρ0) SiHa cancer cells after 48 hours DCA 5 mM treatment. Medium containing no FBS was used as positive control in proliferation experiments. Two-sided t test A.-C. or one-way ANOVA with Bonferroni post-hoc test D.-E. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant. Results are expressed as the relative change from control cells and as means ± SEM.