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A. Intracellular NADP+ and NADPH levels measured in MDA-MB-231 cancer cells treated with ± DCA (5 mM, 48 h) and ± 6-AN (100 μM, 48 h). B. Intracellular NADP+ and NADPH levels measured in MDA-MB-231 cancer cells transfected with siRNAs against G6PD (siG6PD) or non-targeting siRNAs (siCTL) and treated with ± DCA. One-way ANOVA with Bonferroni post-hoc test. *p < 0.05, ns, not significant. Results are expressed as means ± SEM.
