Skip to main content
. 2015 Dec 8;7(3):2968–2984. doi: 10.18632/oncotarget.6502

Figure 6. Antitumor effects of administration of FK866, APCP and FK866+ APCP in OVCAR- 3 bearing mice.

Figure 6

(A, B) Tumors were collected from animals treated for 28 days with vehicle (control), or FK866 or APCP or their combination: tumor tissue sections were stained with an anti-Ki67 antibody (A) or with Hematoxilyn/Eosin solution (B); the number of Ki67+ cells was evaluated in randomly chosen fields from different samples (n = 5 fields/sample); the necrotic areas were quantified using the Image J program and results represent the percentage of necrotic area relative to the total section and are the mean ± SD of at least 4 samples. *p < 0.05; **p < 0.01; ***p < 0.001. Representative images are shown. (C) Animals were treated with vehicle (control, black), or FK866 (blue) or APCP (red) or their combination (green) and were sacrificed when they showed signs of poor health. Survival curves were constructed by using the Kaplan–Meier method. Statistical analysis of different treatment groups was performed by Peto's log-rank test. *p < 0.05 vs black, blue and red lines.