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. 2015 Dec 12;7(3):3018–3032. doi: 10.18632/oncotarget.6576

Figure 5. Loss of heterozygosity of NDN is found in a fraction of ovarian cancers.

Figure 5

A. Strategy for LOH detection using SNP genotyping. The arrow indicates the transcription start site and direction. The dotted lines indicate the size and location of the PCR products containing 5 SNPs. B. Two examples of LOH detected in paired patient samples using Sanger based sequencing for rs2192206 and rs754438249. The arrows point out the SNPs with double peaks in the normal tissue which turned to a single peak or a smaller peak in the tumor tissue from the same patient, suggesting loss of one allele. C. Fraction of ovarian cancers with LOH in 43 cases. D. Copy number variation from TCGA database. E. The correlation between copy number and gene expression using the Spearman's rank correlation test.