Table 1. Univariate and multivariate Cox regression analysis for the association of ANXA1 staining with TTP.

		Univariate			Multivariate
	n of patients	HR	95% CI	P	HR	95% CI	P
ANXA1
Negative	272	1.00			1.00
Positive	45	2.99	2.14 – 4.16	< 0.001	1.82	1.12 – 3.00	0.016
Age
≤ 55 years	125	1.00			1.00
> 55 years	192	0.59	0.47 – 0.75	< 0.001	0.56	0.42 – 0.75	< 0.001
Disease-free survival
≤ 12 months	67	1.00			1.00
> 12 months	250	0.69	0.52 – 0.91	0.008	0.72	0.51 – 1.01	0.057
Dominant site of relapse
Loco-regional	43	1.00
Bone	113	1.20	0.83 – 1.74	0.235
Visceral	74	1.27	0.85 – 1.89	0.238
Bone and other	87	1.25	0.85 – 1.84	0.258
PgR*
Negative	111	1.00			1.00
Positive	204	0.51	0.40 – 0.64	< 0.001	0.71	0.52 – 0.97	0.034
Her2 status*
Negative	201	1.00
Positive	114	1.18	0.93 – 1.50	0.170
Tumor differentiation*
Good	46	1.00			1.00
Moderate	150	1.45	1.01 – 2.06	0.042	1.15	0.79 – 1.67	0.456
Poor	118	1.95	1.35 – 2.82	< 0.001	1.24	0.82 – 1.89	0.311

^*Missing data not reported.

Tumor differentiation was assessed through Bloom-Richardson scoring system.

Acronym: PgR: progesterone receptor.