Table 2. Univariate and multivariate Cox regression analysis for the association of CALD1 staining with TTP.

		Univariate			Multivariate
	n of patients	HR	95% CI	P	HR	95% CI	P
CALD1
Negative	238	1.00			1.00
Positive	21	2.43	1.52 – 3.89	< 0.001	2.29	1.40 – 3.75	0.001
Age*
≤ 55 years	109	1.00			1.00
> 55 years	150	0.64	0.50 – 0.83	0.001	0.55	0.41 – 0.73	< 0.001
Disease-free survival
≤ 12 months	45	1.00			1.00
> 12 months	214	0.72	0.52 – 1.00	0.052	0.76	0.52 – 1.11	0.158
Dominant site of relapse
Loco-regional	29	1.00
Bone	103	1.36	0.88 – 2.12	0.166
Visceral	58	1.34	0.83 – 2.16	0.229
Bone and other	69	1.47	0.92 – 2.34	0.105
PgR
Negative	65	1.00			1.00
Positive	194	0.73	0.54 – 0.97	0.031	0.70	0.50 – 0.96	0.029
Her2 status**
Negative	158	1.00
Positive	79	1.18	0.91 – 1.54	0.221
Tumor differentiation**
Good	37	1.00
Moderate	186	1.21	0.82 – 1.77	0.333
Poor	35	1.5	1.00 – 2.26	0.051

^*Age was assessed at start of tamoxifen therapy.

^**Missing data not reported.

Tumor differentiation was assessed through Bloom-Richardson scoring system.

Acronym: PgR: progesterone receptor