Table 4. Cox proportional hazards regression model analysis of recurrence-free survival and progression-free survival in NMIBC patients.
| Parameters | Categories | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| RFS | |||||
| Age | <67 VS <67 | 1.058(0.689∼1.624) | 0.797 | NA | |
| Gender | Male VS Female | 1.465(0.906∼2.368) | 0.119 | NA | |
| Tumor size | <3cm VS <3cm | 1.280(0.834∼1.965) | 0.259 | NA | |
| Multifocality | Focal VS Multifocal | 0.665(0.421∼1.052) | 0.081 | NA | |
| Concomitant CIS | Yes VS No | 5.247(3.321∼8.289) | <0.001 | 8.445(4.873∼14.636) | <0.001 |
| Stage | Ta VS T1 | 1.937(1.261∼2.977) | 0.003 | 0.861(0.519∼1.428) | 0.562 |
| Grade | Low VS High | 2.892(1.776∼4.712) | <0.001 | 2.256(1.268∼4.013) | 0.006 |
| miR-155 | Negative VS Positive | 2.043(1.083∼3.854) | 0.027 | 3.497(1.722∼7.099) | 0.001 |
| PFS | |||||
| Age | <67 VS <67 | 1.473(0.754∼2.880) | 0.257 | NA | |
| Gender | Male VS Female | 1.462(0.705∼3.034) | 0.307 | NA | |
| Tumor size | <3cm VS <3cm | 1.342(0.698∼2.580) | 0.379 | NA | |
| Multifocality | Focal VS Multifocal | 0.634(0.312∼1.290) | 0.209 | NA | |
| Concomitant CIS | Yes VS No | 4.800(2.423∼9.508) | <0.001 | 5.420(2.535∼11.586) | <0.001 |
| Stage | Ta VS T1 | 9.927(3.856∼25.554) | <0.001 | 3.368(1.153∼9.840) | 0.026 |
| Grade | Low VS High | 16.231(3.894∼67.647) | <0.001 | 4.361(0.858∼22.177) | 0.076 |
| miR-155 | Negative VS Positive | 10.146(1.389∼74.091) | 0.022 | 9.466(1.210∼74.066) | 0.032 |
Abbreviations: RFS, Recurrence-free survival; PFS, Progression-free survival; VS, versus; HR, Hazard ratio; CI, Confidence interval; CIS, Carcinoma in situ; NA, not considered in the multivariable model.