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. 2016 Apr 7;10:92. doi: 10.3389/fncel.2016.00092

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Copyright © 2016 Zrenner, Belardinelli, Müller-Dahlhaus and Ziemann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preliminary results from a millisecond latency EEG-TMS set-up. (A) Simplified implementation of a closed-loop brain-state dependent brain-stimulation set-up consisting of EEG stage, real-time digital signal processing stage, and a triggered stimulation stage. (B) Raw EEG traces recorded from electrode C3 in the period before a TMS 100 Hz triplet pulse that is triggered by a real-time system based on the preceding 300 ms of EEG data. The system can be configured to trigger the stimulation either at the trough (top trace) or at the peak (bottom trace) of spontaneous alpha activity recorded by EEG over motor cortex.