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Effect of VPA-induced histone hyper-acetylation on cardiac reprogramming. (A) Sarc MyHC and Nppa expressed in transduced cells is shown as the fold increase compared to flat substrate without VPA (***p < 0.001, **p < 0.01, *p < 0.05; Student's t-test against the flat control, n = 63, error bars indicate standard deviation). (B) Western Blot showing the increase in AcH3 following incubation for 24 h with 0.5 mM VPA.
