Table 3.
Statistical analysis of azilsartan plasma pharmacokinetic parameters according to age, sex, and race
| Parameter | LS mean | LS mean | Ratio [90 % CI] |
|---|---|---|---|
| Age | Elderly (n = 23) | Young (n = 24) | Elderly/young |
| Single dose (Day 1) | |||
| AUC0–∞ (ng·h/mL) | 26,003a | 19,062b | 1.36 [1.05, 1.77] |
| C max (ng/mL) | 2876 | 2093 | 1.37 [1.02, 1.86] |
| Multiple dose (Day 8) | |||
| AUC0–24 (ng·h/mL) | 24,375 | 19,384 | 1.26 [1.01, 1.57] |
| C max (ng/mL) | 3036 | 2638 | 1.15 [0.89, 1.49] |
| Sex | Female (n = 23) | Male (n = 24) | Female/male |
| Single dose (Day 1) | |||
| AUC0–∞ (ng·h/mL) | 22,577a | 21,955b | 1.03 [0.78, 1.36] |
| C max (ng/mL) | 2478 | 2430 | 1.02 [0.75, 1.39] |
| Multiple dose (Day 8) | |||
| AUC0–24 (ng·h/mL) | 22,565 | 20,938 | 1.08 [0.86, 1.36] |
| C max (ng/mL) | 3049 | 2627 | 1.16 [0.89, 1.52] |
| Race | White (n = 24) | Black (n = 23) | White/black |
| Single dose (Day 1) | |||
| AUC0–∞ (ng·h/mL) | 24,599b | 20,150a | 1.22 [0.95, 1.58] |
| C max (ng/mL) | 2547 | 2364 | 1.08 [0.81, 1.44] |
| Multiple dose (Day 8) | |||
| AUC0–24 (ng·h/mL) | 22,974 | 20,565 | 1.12 [0.90, 1.39] |
| C max (ng/mL) | 3201 | 2502 | 1.28 [0.99, 1.65] |
CI confidence interval, AUC 0–24h area under the plasma concentration-time curve from time 0 to 24 h post dose, AUC 0–∞ area under the plasma concentration-time curve from time 0 h to infinity, C max maximum observed drug concentration in plasma
a n = 22
b n = 23