Table 4. Multivariate analysis of recurrence-free survival.
| Variable | Hazard ratio | 95% CI | p-value |
|---|---|---|---|
| Diabetes mellitus | 0.051 | ||
| No | 1 | - | |
| Yes | 2.68 | 1.10-6.54 | |
| Age (yr) | 0.007 | ||
| <40 | 2.82 | 1.47-5.40 | |
| 40-59 | 1 | - | |
| ≥60 | 1.87 | 0.72-4.85 | |
| Histology | 0.006 | ||
| Squamous cell carcinoma | 1 | - | |
| Adenocarcinoma | 0.85 | 0.41-1.75 | |
| Adenosquamous carcinoma | 2.23 | 0.83-6.02 | |
| Other | 6.61 | 2.44-17.94 | |
| Deep stromal invasion | 0.007 | ||
| No | 1 | - | |
| Yes | 2.53 | 1.32-4.87 | |
| Diabetes mellitus (time-varying-effect Cox model) | |||
| In first 5 years | 0.276 | ||
| No | 1 | - | |
| Yes | 1.89 | 0.65-5.50 | |
| After 5 years | 0.022 | ||
| No | 1 | - | |
| Yes | 11.15 | 2.00-62.08 | |
| Age (yr) | 0.009 | ||
| <40 | 2.74 | 1.43-5.25 | |
| 40-59 | 1 | - | |
| ≥60 | 1.96 | 0.76-5.10 | |
| Histology | 0.007 | ||
| Squamous cell carcinoma | 1 | - | |
| Adenocarcinoma | 0.86 | 0.41-1.78 | |
| Adenosquamous carcinoma | 2.21 | 0.82-5.97 | |
| Other | 6.53 | 2.41-17.71 | |
| Deep stromal invasion | 0.007 | ||
| No | 1 | - | |
| Yes | 2.56 | 1.32-4.94 |