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. 2016 Mar 25;2(1):e000143. doi: 10.1136/rmdopen-2015-000143

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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Kaplan-Meier Curves showing drug survival in strategy arms 1 and 2. (A) Initial methotrexate monotherapy, n=84; (B) Switching to sulfasalazine monotherapy in strategy arm 1, adding sulfasalazine to methotrexate in strategy arm 2, n=46; (C) Switching to leflunomide monotherapy in strategy arm 1, adding hydroxychloroquine to methotrexate and sulpsalazine in strategy arm 2, n=35. Discontinuation of drugs is due to insufficient response, toxicity or other reasons. The lines indicate the percentage of patients in strategy arms 1 and 2 who are treated according to the concerned treatment step.