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. 2016 Mar 20;4(5):e12625. doi: 10.14814/phy2.12625

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Combined pharmacological AMPK and PPARδ activation modifies hepatic mRNA expression of PGC‐1α and CHREBP in trained mice. After exhaustion, liver was analyzed for Pgc1a, and Chrebp expression. Data were normalized to Hprt expression, rationalized to SED, and expressed as means ± SEM (n = 7–8). Significant differences were analyzed by one‐way ANOVA followed by Newman‐Keuls multiple comparison test. Asterisk (*), plus sign (+), slash (/) and dagger (†) represent significant difference relative to SED, V, G and A, respectively. Single symbols, P < 0.05 while triple symbols, P < 0.001.