Table 2.
Effects of various doses of adrenomedullin (ADM) on angiotensin II (AngII)-induced 3H-TdR incorporation and protein kinase C (PKC) activityin vascular smooth muscle cells (VSMCs)
| Group | 3H-TdR incorporation (cpm/well) | PKC activity (pmol pi/mg protein) |
|---|---|---|
| Control | 2159.64±483.25 | 486.±126.17 |
| AngII10-8mol/l | 7946.26±464.27# | 980.25±142.15# |
| Ang II 10-8mol/l+ADM 10-9mol/l | 4107.00±259.70* | 923.25±112.45* |
| Ang II 10-8mol/l+ADM 10-8mol/l | 3768.47±317.40* | 736.75±128.51* |
| Ang II 10-8mol/l+ADM 10-7mol/l | 3285.37±264.22* | 631.25±110.04* |
Results are presented as x̄ ±SE n=6
#
P<0.01 vs. Control
*
P<0.01vs. AngII 10-8mol/l group cpm, counts per million