Table 3.
Effects of various doses of proadrenomedullin N- terminal 20 peptide (PAMP) on angiotensin II (AngII)-induced 3H-TdR incorporation and protein kinase C (PKC) activity in vascular smooth muscle cells (VSMCs)
| Group | 3H-TdR incorporation (cpm/well) | PKC activity (pmol pi/mg protein) |
|---|---|---|
| Control | 2159.64±193.30 | 486±50.47 |
| AngII10-8mol/l | 7946.26 ±185.71# | 980.25±56.86# |
| AngII10-8mol/l+ PAMP10-9mol/l | 3802.06±133.43* | 897.5 ±25.22* |
| AngII10-8mol/l+PAMP 10-8mol/l | 3356.17±134.3* | 789.00±44.4* |
| AngII10-8mol/l+PAMP 10-7mol/l | 3041.69±88.6* | 717.00±33.56* |
Results are presented as x̄±SEM, n=6
#
P<0.01 vs. Control
*
P<0.01vs. AngII 10-8mol/l group
cpm, counts per million