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. 2016 Apr 7;6:23914. doi: 10.1038/srep23914

Figure 6. 82-kDa ChAT and SATB1 associate with shared cell membrane and stress related genes after Aβ-exposure.

Figure 6

(A) Number of genes associated with ChIP-seq peaks for 82-kDa ChAT and/or SATB1 after treatment of cells with vehicle or 100 nM oligomeric Aβ1–42. There was increased gene association between the proteins after exposure of cells to Aβ. (B) Gene ontology analysis for groups of gene associations found by ChIP-seq. 82-kDa ChAT and SATB1 had significant associations with genes encoding proteins involved in synapse function, cell adhesion and cell membrane function with both treatments. For genes associated with both 82-kDa ChAT and SATB1 after exposure to Aβ1–42, there were significant gene associations for nucleoside binding and programmed cell death (box). Gene ontology terms are presented with the -log value of the false discovery rate (FDR).