Figure 1. Infection and vaccination schedule.

The mice were aerosol challenged with the Mtb H37Rv strain and animals were sc immunized twice with L91 at 4 wk and 6 wk of Mtb post-infection (pi). The drugs (INH + RIF) were orally administered in drinking water from 4 wk to 8 wk of pi. The bacterial burden in the lungs and spleen was enumerated at 20 wk and 32 wk of pi. In vitro T cell recall response was evaluated at 20 wk of pi.