Figure 5. Changes in systolic blood pressure (SBP) in spontaneously hypertensive rats after oral administration of a water extract of Tricholoma matsutake and purified ACE inhibitor TMP.

(a) Single oral administration was performed with a dosage of 200 mg water extract/kg body weight and 400 mg water extract/kg body weight, respectively. SBP was measured 0, 0.5, 2, 4, 6 and 8 h after administration. (*)Significantly different from control at p < 0.05 by student’s t-test. (●) control, 0.9% saline solution; (◼) captopril; (Δ) 200 mg water extract/kg body weight; (▴) 400 mg water extract/kg body weight. (b) Single oral administration was performed with a dosage of 25 mg TMP/kg body weight and 50 mg TMP/kg body weight, respectively. SBP was measured 0, 0.5, 2, 4, 6 and 8 h after administration. (*)Significantly different from control at p < 0.05 by student’s t-test. (●) control, 0.9% saline solution; (▪) captopril; (▵) 25 mg TMP/kg body weight; (▴) 50 mg TMP/kg body weight.