Table 1.

Advantages and Disadvantages of the Yolk Sac or Brain for Glioma Cell Implantation.

Yolk Sac		Brain
Advantages	Disadvantages	Advantages	Disadvantages
Studying angiogenic effects is straightforward	Yolk sac is degraded after a few days	Is a permanent structure	Studying angiogenic effects may be difficult
	Survival and proliferation of glioma cells are limited	Glioma cells survive and proliferate better
	Limited suitability for studying cell invasion	Suitable for studying cell invasion
		Orthotopic implantation may give more relevant results