Figure 1. Oncogenic alterations in 41 sub-regions from nine DIPG patients from whole exome sequencing data.

Samples representing different anatomical locations within each patient are represented in columns. The mutations (in rows) were selected based on published datasets in paediatric glioblastoma and specifically DIPG. Mutations were divided into two subgroups; driver mutations which are essential for tumour initiation/maintenance and accessory driver mutations, which can further promote and accelerate tumour growth, but are not absolutely essential for tumour initiation or maintenance.