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. 2016 Apr 6;17:150. doi: 10.1186/s12891-016-0995-x

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© Cheng et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The Beclin-1 and LC3 expression in rabbit OA model. a The protein expression of Beclin-1 and LC3 evaluated by western blotting. b, c Quantitative analysis showed a significantly reduction of Beclin-1 expression and the LC3B-II/LC3B-I ratio in the collagenase-injected group compared with the control group. Similarly, expression levels of Beclin-1 and the LC3B-II/LC3B-I ratio were much higher in the Torin 1-treated group than in the collagenase-injected group, while they were lower in the 3-MA-treated group. n = 3 for each group. *P < 0.05, **P < 0.01, ***P < 0.001