Table 1.
Baseline characteristics
| Total n = 524 | |
|---|---|
| Demographics | |
| Mean age (SD), years | 57.7 (12.1) |
| Age (n (%)) | |
| 18 to <35 | 23 (4.4) |
| 35 to <60 | 262 (50) |
| 60 to <70 | 151 (28.8) |
| ≥70 | 88 (16.8) |
| Women (n (%)) | 185 (35.3) |
| Race (n (%)) | |
| Caucasian | 374 (71.4) |
| Asian | 15 (2.9) |
| Black | 19 (3.6) |
| Indian subcontinent | 12 (2.3) |
| Aboriginal | 9 (1.7) |
| Other | 16 (3.1) |
| Unknown | 34 (6.5) |
| Missing | 45 (8.6) |
| Income quintile (n (%)) | |
| One (lowest) | 114 (21.8) |
| Two | 106 (20.2) |
| Three | 102 (19.5) |
| Four | 83 (15.8) |
| Five (highest) | 119 (22.7) |
| Rural location (n (%)) | 102 (19.5) |
| Year of cohort entry (n (%)) | |
| 2003–2006 | 149 (28.4) |
| 2007–2009 | 159 (30.4) |
| 2010–2012 | 216 (41.2) |
| Time since transplant, median (IQR), years | 3.5 (1.5, 7.1) |
| Year of kidney transplant (n (%)) | |
| 1988–1992 | 18 (3.4) |
| 1993–1997 | 39 (7.45) |
| 1998–2002 | 147 (28.1) |
| 2003–2007 | 205 (39.1) |
| 2008–2012 | 115 (21.9) |
| Time on dialysis prior to transplant, median (IQR), years | 2.0 (0.9, 3.5) |
| Time on dialysis prior to transplant (n (%)), years | |
| 0 to <1 | 121 (23.1) |
| 1 to <2 | 118 (22.5) |
| 2 to <3 | 82 (15.7) |
| 3 to <4 | 57 (10.9) |
| ≥4 | 98 (18.7) |
| Cause of end stage renal disease (n (%)) | |
| Glomerulonephritis | 148 (28.2) |
| Hypertension | 49 (9.4) |
| Pyelonephritis/interstitial | 35 (6.7) |
| Cystic kidney disease | 61 (11.6) |
| Diabetes | 108 (20.6) |
| Other | 29 (5.5) |
| Unknown | 94 (17.9) |
| Type of donor (n (%)) | |
| Deceased | 347 (66.2) |
| Living | 165 (31.5) |
| Missing | 12 (2.3) |
| Comorbidities (n (%)) | |
| Coronary artery disease | 156 (29.8) |
| Diabetes | 243 (46.4) |
| Hypertension | 489 (93.3) |
| Congestive heart failure | 88 (16.8) |
| Chronic liver disease | 36 (6.9) |
| Chronic obstructive pulmonary disease | 20 (3.8) |
| Peripheral vascular disease | 28 (5.3) |
| Stroke/transient ischemic attack | 12 (2.3) |
| Baseline laboratory measurements | |
| Serum creatinine, median (IQR), umol/L | 133.0 (103.0, 173.9) |
| eGFR, median (IQR), ml/min/1.73 m2a | 46.1 (33.4, 62.8) |
| eGFR category (n (%)), ml/min/1.73 m2 | |
| <15 | 21 (4.0) |
| 15 to <30 | 84 (16.0) |
| 30 to <45 | 146 (27.9) |
| 45 to <60 | 116 (22.1) |
| ≥60 | 157 (30.0) |
| AKI definitions (n (%))b | |
| Any AKI | 236 (45.0) |
| AKIN stage 1 | 160 (30.5) |
| AKIN stage 2 | 21 (4.0) |
| AKIN stage 3 | 55 (10.5) |
aEstimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation [32]
bDefined by serum creatinine